You think, “I’m a man, there’s no way I’m going to feel like I’m in menopause.” Prednisone can make you feel like you’re a menopausal woman and you can get hot flashes with the sweating, the redness, the flushing, and even the mood changes. So even in men, hot flashes are possible. Usually, these things go back to normal when you stopped taking prednisone. Two men report that their penis is smaller while taking prednisone than it usually is. Often prednisone causes weight gain and fat redistribution, and that might happen in the breast area. It’s possible that a man could have changes in his breasts. I’m going to get man boobs!” No this is very, very rare. Don’t think, “Oh no, my doctor prescribed prednisone. Prednisone Side Effects from Female Hormones:īecause prednisone looks like those female hormones progesterone and estrogen, some men report changes in their physical anatomy.Female Hormones: Progesterone and Estrogens I’ll explain how prednisone affects men differently than women by first showing how changes in female hormones cause side effects, then how changes in male hormones cause prednisone side effects. Prednisone Side Effects in Men Hormonal Issues It can interfere with the normal rhythm of these hormones and the cascade, how they switch between structures, can be messed up. Our bodies can get confused when taking prednisone. Prednisone Chemical Structure is similar to Testosterone, Estrogens and Progesterone This explains many of the prednisone side effects in men. Prednisone mimics cortisol and sex steroid hormones like testosterone, estradiol, and progesterone. They all look pretty similar: they all have these four six-sided circles that connect and kind of match each other.The female hormones, progesterone and estrogen.On the bottom, there are the sex hormones: Prednisone is mimicking cortisol on the top, or our “wear and tear” hormone, that affects our ability to deal with stress. On the right in the second image below, you can see all the different hormones that are in our bodies, including steroid hormones. You see prednisone there below, and in the second image, below, on the left (cortisol). It looks like other structures, other signals, called hormones. Watch now!įind out what you can do to fight back! Why Side Effects: The Chemical Structure of PrednisoneĪs an introduction into the reason why many of the side effects in men appear, we need to understand the basic science. Since prednisone is a steroid, it affects men differently than women.Ĭheck out this video to explain in more depth which adverse effects of prednisone men might expect. I searched many articles, prescription drug databases, and patient support groups to compile this list of prednisone side effects in men. Many men prescribed prednisone wonder: what are the prednisone side effects in men? How will the adverse effects in males differ from those in females?
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